There are differences in all colors, it's not just a matter of using a "cyan" ink in the cyan chamber, but the correct one to color match your printer model. To get correct color using inks not designed for the printer you're using, you will need to use color profiles for your specific printer model, ink combination, and paper- otherwise your color will be off. It's best to use a full set of InkThrift Pro inks for the R2400 printer, which are color matched to that printer model. If you don't care at all about color (which I doubt, since you're asking about longevity), then you can certainly try using InkThrift CL in your R2400 printer, but we don't know what your results will look like, nor support this ink/printer combination.
I hope this helps.
best regards~ Dana