I just responded to your other post regarding the issue you're having after installing the MK refillable cart. After reading this post, I see you have at least the VLM (Vivid light magenta, not "very" light) and MK carts installed, I assume these are the only two you have installed so far.
We carefully formulated ConeColor Pro inks to be such a close match that inks can be installed one at a time as Epson carts empty, and continue getting great results using the standard Epson workflow/profiles. What colors/subjects are you printing that shirted orange? If you could attache an image or two that show the orange shift you're experiencing, it would be helpful for me to see. Instructions for attaching images to this forum can be found here: http://www.inkjetmall.com/tech/content.php?152-How-to-attach-images-to-this-forum
What paper/profiles are you using?
It takes several prints or 2-3 power clean cycles to move ink from the cartridge to the print head, so a change in output wouldn't show up immediately after replacing a cartridge.
Did you shake the ink bottle before drawing ink out and filling the cartridge, or had the ink bottle been sitting since you purchased them a few months ago, and you drew ink from the top of the bottle to fill the cartridge?
Please let me know so I can help you resolve this and get back to happily printing.
Best regards~ Dana