Adobe Color Printing Utility on Mac

Since custom profiles are created using Adobe CPU, do we then also need to print from ACPU instead of PS to keep the Mac OS X 10.11 or 10.12 from altering the color values during printing?

Printing from ACPU is only necessary when printing targets to have a new profile made, because they MUST be printed with NO color management. Once the profile is made, you can print with it thru Photoshop by selecting it in the profile pull down list and turning printer color management off in the print driver.